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Retatrutide vs Tirzepatide

Triple agonist against dual agonist: what the third receptor changes.

Reference only. This page covers what the compound is, how it is presented and how it is handled. It does not give dosing protocols or administration schedules, and it is not medical advice.
RetatrutideTirzepatide
ClassTriple agonist, GIP / GLP-1 / glucagon receptorDual agonist, GIP and GLP-1 receptor
FamilyMetabolicMetabolic
Content40 mg40 mg
Fill volume3 ml3 ml
Per dial unit133 mcg133 mcg
Cost£5.25 per mg£4.38 per mg
Stockin stockin stock

Retatrutide

Retatrutide acts at three receptors: GIP, GLP-1 and glucagon. That third arm is what separates it from tirzepatide, which is a dual GIP and GLP-1 agonist, and from semaglutide, which acts at GLP-1 alone. It is the most recent of the three and carries the least published data.

Tirzepatide

Tirzepatide binds both the GIP and GLP-1 receptors. It sits between the single agonists and retatrutide in receptor coverage, and carries considerably more published data than retatrutide does.

Stocked at The PED Shop

Availability checked 2026-09-04. The product page carries live stock.

Brands stockedQUANTASerenQ